Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetHMG-CoA reductase

General description

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G₁ phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.Endo, A. 1992. J. Lipid Res.33, 1569.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)